These bumps may be the first sign of keratosis follicularis. Heat or sun often causes an outbreak.Īnother common finding associated with keratosis follicularis is the development of multiple, small, yellow-brown, flattened wart-like (verrucous) bumps (papules) on backs of the hands or feet. Keratosis follicularis is usually worse in the summer and improves in the winter. However, the lesions tend to recur (relapse). Individuals with keratosis follicularis may have periods when few lesions are present (remission). Heat, exercise and sunlight may also worsen keratosis follicularis or cause a new outbreak of lesions. The herpes simplex virus may be prone to infecting the lesions and causes pain.
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Infected skin lesions may give off a distinct, unpleasant (malodorous) smell. The skin may develop bacterial, viral or fungal infections (secondary infections) that worsen (exacerbate) the condition. Some patients have fragile skin that blisters or becomes raw (erosions) and painful. The lesions may cause persistent itchiness (pruritus). In extremely rare, severe cases, almost the entire body may be affected. The lesions will slowly grow bigger eventually coming together (coalescing) to form discolored, warty plaques that may cover extensive areas of the body particularly on the trunk. The skin lesions associated with keratosis follicularis generally develop a brown, greasy crust and become thickened and warty (hyperkeratotic), scaly and darkened. Darier disease may also affect skin creases e.g. The lesions usually affect the areas of the body near sebaceous glands (sebaceous glands secrete oily grease) including the chest, back, forehead and scalp. The initial lesions in keratosis follicularis are usually small, firm, greasy bumps (papules) that are often skin-colored, brown or yellow-brown in color. The severity of the disorder and the specific symptoms that develop vary, even among individuals within the same family. Symptoms may develop in younger or older individuals, but rarely develop after the third or fourth decade of life. The symptoms of keratosis follicularis usually become apparent during the teen-age years often around puberty. 5 Myths About Orphan Drugs and the Orphan Drug Act.